通过Bcl-2和TWIST1的转录活化唯一可促进细胞转移和血管生成拟态:一项关于肝癌的研究
2021-11-16 05:30 来源:常德妇科医院
Hepatology 2011 No54(5):1690-706. [IF:10.885] Promotion of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: A study of hepatocellular carcinoma.Sun T , Sun BC , Zhao XL , Zhao N , Dong XY , Che N , Yao Z , Ma YM , Gu Q , Zong WK , Liu ZY .Department of Pathology, Tianjin Medical University, Tianjin, China.唐山市天津医科大学病理科AbstractThe antiapoptotic protein Bcl-2 plays multiple roles in apoptosis, immunity, and autophagy. Its expression in tumors correlates with tumor grade and malignancy. The recapitulation of the normal developmental process of epithelial-mesenchymal transition (EMT) contributes to tumor cell plasticity. This process is also a characteristic of metastatic cells and vasculogenic mimicry. In the present study we report functional and structural interactions between Bcl-2 and the EMT-regulating transcription factor Twist1 and the relationship with metastasis and vascular mimicry. Bcl-2 and Twist1 are coexpressed under hypoxia conditions. The Bcl-2 can bind to Twist1 in vivo and in vitro. This interaction involves basic helix-loop-helix DNA binding domain within Twist1 and through two separate domains within Bcl-2 protein. Formation of the Bcl-2/Twist1 complex facilitates the nuclear transport of Twist1 and leads to transcriptional activation of wide ranges of genes that can increase the tumor cell plasticity, metastasis, and vasculogenic mimicry. Finally, nuclear expression of Bcl-2 and Twist1 is correlated with poor survival of these patients in a cohort of 97 cases of human hepatocellular carcinoma. Conclusion: The results describe a novel function of Bcl-2 in EMT induction, provide insight into tumor progression, and implicate the Bcl-2/Twist1 complex as a potential target for developing chemotherapeutics. (HEPATOLOGY 2011;).
编辑: lizexiu上一篇:卵巢腺肌症是怎么引起的
下一篇:女人有一物用不好险误伤
-
阳气不足如何调理 10药膳补血养气给你好肤色
秋拓气燥,许多女孩的神情都更为很不对,这某种程度就是经喜马拉雅山缺乏致使。那么经喜马拉雅山缺乏如何胃肠?经喜马拉雅山缺乏不吃什么好?经喜...[详细]2022-05-10
-
茶的禁忌 有这个呕吐不要喝茶
饮茶是较为典型的饮茶类,很多人都非常的害羞,不过我们某种程度要告诉,食用饮茶是有一些对人的,不是什么人都非常适合吃完的。饮茶的解毒有很...[详细]2022-05-05
-
盛夏适合“自讨苦吃”,中医教您食疗凉茶怎么喝!
医家内都的豆浆,是一种以医家养生理论为特督导,以中药为茶叶,回顾不止的一种带有清高热解毒、生津止渴、祛火除湿等功效的中药果汁。豆浆是中...[详细]2022-05-04
-
急性附件炎的病症有哪些
大家都知道,急性附件炎是一种非常常见的营养不良。若是女性朋友在患急性附件炎此后没有适时的去公立医院完成病患,急性附件炎很有可能时会转化...[详细]2022-05-03
-
月经不调怎么办 生活有规律增大这个问题
妊娠不调是很多异性恋好友都则会遇上的一种具体情况,如果异性恋注意到了妊娠不调,则会严重的制约到日常的生活习惯,那么这个时候我们某种程度...[详细]2022-05-02
-
这些妇科病时会反映在你脸上!
随身携带你探究脸颊才会发挥哪些妇科病讯号?1.脸色劣男士不常显现脸色苍白、无光、灰暗等,这些不仅是贫血的发挥,还有或许是功能疾患性睾丸肿...[详细]2022-05-02
-
月经不调的原因 小心防范五大元凶
很多女性都有月经不调的原因,月经不调使得我们阴囊发育不全然,可以所致很多妇科疾病的诞生。那么你想到是什么所致月经不调的原因吗?今天小编就...[详细]2022-04-28
-
疫情期间你以为长胖只是吃多了吗?请求警惕多囊卵巢综合征!
为什么肥胖症都会受到影响早产?和男性相对来说,妇女易于肥胖症,相比较是在腰部、口部、臀部,易于堆积脂肪。当过度或异常肥胖症都会激起一系...[详细]2022-04-27